Cell Line Development

Transfect genes coding candidate drug products
Apply selection pressure to isolate cells with desired genes
Single cell cloning

High-resolution imaging enables documentation of precise single-cell deposition

Photographic monoclonality evidence supports regulatory compliance

Eﬀicient processes reduce timelines for regulatory approval

Verified In-situ Plate Seeding Deposits a single cell per well in 96- or 384-well plates

Image verification of single cell at drop level Well is then filled with growth media

Images entire well Shows outgrowth of single cell across several days

Single cell deposition and high-resolution imaging provide FDA & regulatory agencies with documented evidence of manufacturing cell line clonality