Cell Line, Process & Product Development

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Stable Cell Line Production

Transfect genes coding candidate drug products
Apply selection pressure to isolate cells with desired genes
Single cell cloning

VIPS automated single cell deposition and imaging

High-resolution imaging enables documentation of precise single-cell deposition

Cell Metric Documented Clonality

Photographic monoclonality evidence supports regulatory compliance

Streamlined Clinical Progression

Efficient processes reduce timelines for regulatory approval

Process Development & Scale-Up

Upstream & Downstream Optimization

Ensures efficient high-yield processes

High-Throughput Screening

Ambr bioreactors accelerate process refinement with the aid of Design of Experiment methodologies

Scalable Bioreactor Systems

XDR-10 & BioBLU enable seamless scale-up

Cutting-Edge Analytical Tools

Fine-tune critical parameters for yield, purity, and manufacturability

GMP-Ready Platforms

Smooth transition from lab-scale to clinical production

Accelerated Time-to-Market

Optimized workflows speed up therapeutic development

Characterization Methods

CQA Method Instrument
Content Amino Acid Analysis Agilent 1100 HPLC
Copy Number 7500 FAST qPCR
Function Binding Kinetics by Biolayer Interferometry Octet Red384
Structure & Post Translational Modifications Peptide Mapping Mass Spec & Agilent 1290 UHPLC
Intact Molecular Weight Mass Spec & Agilent 1290 UHPLC
Subunit Molecular Weight Mass Spec & Agilent 1290 UHPLC
N-Glycan Profile Mass Spec & Agilent 1290 UHPLC – FLD

Sartorius Octet Red384 System

Agilent 6545 XT Q-ToF Mass Spectrometer